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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. During a primary infection with Epstein-Barr virus (EBV), the virus establishes latency in B lymphocytes.
The transition from lytic to latent infection is tightly regulated by viral gene expression. Which of the following viral proteins is crucial for the establishment and maintenance of EBV latency and is a key target in EBV-associated lymphomas?

A) Viral capsid antigen (VCA)
B) Epstein-Barr nuclear antigen 1 (EBNA1)
C) Early antigen (EA)
D) Glycoprotein gp350

2. The primary mechanism of action of aminoglycoside antibiotics, such as gentamicin, involves:

A) Inhibition of bacterial DNA gyrase and topoisomerase IV
B) Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins
C) Disruption of bacterial cell membrane integrity
D) Inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit

3. Vancomycin resistance in Enterococcus faecium, mediated by the vanA gene cluster, results from:

A) Modification of the drug target from D-alanyl-D-alanine to D-alanyl-D-lactate
B) Decreased outer membrane permeability to vancomycin
C) Efflux pump overexpression removing vancomycin from the cell
D) Enzymatic inactivation of vancomycin by phosphorylation

4. A clinical microbiology laboratory is validating a new automated blood culture system. To assess the system's ability to detect true positive results, they should:

A) Compare the time to detection with the current manual blood culture method.
B) Spike known concentrations of various microorganisms into blood culture bottles.
C) Evaluate the system's performance with samples from patients with known bloodstream infections.
D) Process a large number of sterile blood samples.

5. An immunocompromised patient returning from a trip to the southwestern United States presents with fever, cough, and chest pain. Chest X-ray shows diffuse pulmonary infiltrates. Sputum culture grows a dimorphic fungus that forms spherules containing endospores at 37°C. The MOST likely causative agent is:

A) Blastomyces dermatitidis
B) Coccidioides immitis
C) Paracoccidioides brasiliensis
D) Histoplasma capsulatum

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